Publications of the Walvoort Lab

Full list of publications here

* indicates corresponding author, # denotes equal contribution


46. Reintjens, N.R.M.,# Yakovlieva, L.,# Marinus, N., Hekelaar, J., Nuti, F., Papini, A.M., Witte, M.D., Minnaard, A.J., Walvoort, M.T.C.* (2022) ‘Palladium-catalyzed oxidation of glucose in glycopeptides’ EurJOC, accepted Web

45. Ferrari, M., Hameleers, L., Stuart, M.C.A., Oerlemans, M.M.P., de Vos, P., Jurak, E., Walvoort, M.T.C.* (2022) ‘Efficient isolation of membrane-associated exopolysaccharides of four commercial bifidobacterial strains’ Carbohydrate Polymers, vol. 278, p. 118913 Web


44. Lucas, F.L.R., Versloot, R.C.A., Yakovlieva, L., Walvoort, M.T.C., Maglia, G. (2021) ‘Protein identification by nanopore peptide profiling’ Nature Communications, vol. 12, no. 1, p. 1-9 Web

43. Yakovlieva, L., Fülleborn, J., Walvoort, M.T.C.* (2021) ‘Opportunities and challenges of bacterial glycosylation for the development of novel antibacterial strategies’ Frontiers in Microbiology, vol. 12, p. 745702 Web

42. Marinus, N., van Dijk, J.H.M., Walvoort, M.T.C., Witte, M.D., Minnaard, A.J. (2021) ‘Chapter 16: Regioselective palladium catalyzed oxidation at C-3 of methyl glucoside’ Carbohydrate Chemistry: Proven Synthetic Methods, vol. 5, Eds. Kosma, Wrodnigg, Stütz.

41. Yakovlieva, L., Ramirez-Palacios, C., Marrink, S.J., Walvoort, M.T.C.* (2021) ‘Semiprocessive hyperglycosylation of adhesin by bacterial protein N-glycosyltransferases’ ACS Chemical Biology, vol. 16, no. 1, p. 165-175 Web

40. Yakovlieva, L.,# Wood, T.M.,# Kemmink, J., Kotsogianni, I., Koller, R., Lassak, J., Martin, N.I.,* Walvoort, M.T.C.* (2021) ‘A β-hairpin epitope as novel structural requirement for protein arginine rhamnosylation’ Chemical Science, vol. 12, p. 1560-1567 Web

39. Oerlemans, M.M.P., Akkerman, R., Ferrari, M., Walvoort, M.T.C., de Vos, P. (2021) ‘Benefits of bacteria-derived exopolysaccharides on gastrointestinal microbiota, immunity and health’  Journal of Functional Foods, vol. 76, p. 104289 Web

38. Verkhnyatskaya, S.A., Kong, C., Klostermann, C., Schols, H.A., de Vos, P., Walvoort, M.T.C.* (2021) ‘Digestion, fermentation, and pathogen anti-adhesive properties of the hMO-mimic di-fucosyl-β-cyclodextrin’ Food & Function, vol. 12, p. 5018-5026 Web

37. Leeuwenburgh, V.C., Urzúa-Traslaviña, C.G., Bhattacharya, A., Walvoort, M.T.C., Jalving, M., de Jong, S., Fehrmann, R.S.N. (2021) ‘Robust metabolic transcriptional components in 34,494 patient-derived cancer-related samples and cell lines’ BMC Cancer & Metabolism, vol. 9, p. 35 Web


36. Cheng, L., Kiewiet, M.B.G., Logtenberg, M., Groeneveld, A., Nauta, A., Schols, H.A., Walvoort, M.T.C., Harmsen, H.J.M., de Vos, P. (2020) ‘Effects of different human milk oligosaccharides on growth of Bifidobacteria in monoculture and co-culture with Faecalibacterium prausnitziiFrontiers in Microbiology, vol. 11, p. 569700 Web

35. Hu, S., Kuwabara, R., Beukema, M., Ferrari, M., de Haan, B.J., Walvoort, M.T.C., de Vos, P., Smink, S.M. (2020) ‘Low methyl-esterified pectin protects pancreatic β-cells against diabetes-induced oxidative and inflammatory stress via galectin-3’ Carbohydrate Polymers, vol. 249, p. 116863 Web

34. Kong, C., Cheng, L., Krenning, G., Fledderus, J., de Haan, B.J., Walvoort, M.T.C., de Vos, P. (2020) ‘Human milk oligosaccharides mediate the crosstalk between intestinal epithelial Caco-2 cells and Lactobacillus plantarum WCFS1 in an in vitro model with intestinal peristaltic shear force’ The Journal of Nutrition, vol. 150, no. 8, p. 2077-2088 Web

33. Cheng, L., Akkerman, R., Kong, C., Walvoort, M. T. C., de Vos, P. (2020) ‘More than sugar in the milk: human milk oligosaccharides as essential bioactive molecules in breast milk and current insight in beneficial effects’ Critical Reviews in Food Science and Nutrition, p. 1-17. Web

32. Zhang, J., Yakovlieva, L., de Haan, B. J., de Vos, P., Minnaard, A. J., Witte, M. D., Walvoort, M. T. C.* (2020) ‘Selective Modification of Streptozotocin at the C3 Position to Improve Its Bioactivity as Antibiotic and Reduce Its Cytotoxicity towards Insulin-Producing β Cells’ Antibiotics, vol. 9, no. 4, p. 182 Web

31. Yakovlieva, L., Walvoort, M. T. C.* (2020) ‘Processivity in Bacterial Glycosyltransferases’ ACS Chemical Biology, vol. 15, no. 1, pp. 3-16 Web

30. Cheng, L., Kong, C., Walvoort, M. T. C., Faas, M. M., de Vos, P. (2020) ‘Human Milk Oligosaccharides Differently Modulate Goblet Cells Under Homeostatic, Proinflammatory Conditions and ER Stress’ Molecular Nutrition & Food Research, vol. 64, no. 5, p.1900976 Web


29. Verkhnyatskaya, S. A., de Vries, A. H., Douma-de Vries, E., Sneep, E. J. L., Walvoort, M. T. C.* (2019) ‘Direct and Regioselective Di-alpha-fucosylation on the Secondary Rim of beta-Cyclodextrin’ Chemistry A European Journal, vol. 25, no. 27, pp. 6722-6727 Web

with Front Cover art, and author profile: Chemistry A European Journal, vol. 25, no. 27, p. 6649 Web

28. Verkhnyatskaya, S., Ferrari, M., de Vos, P., Walvoort, M. T. C.* (2019) ‘Shaping the Infant Microbiome With Non-digestible Carbohydrates’ Frontiers in Microbiology, vol. 10, no. 343 Web


27. Leeuwenburgh, V., Bhattacharya, A., Urzua, C., Walvoort, M., Jalving, H., de Jong, S., Fehrmann, R. (2018) ‘The metabolic landscape browser: a novel tool for understanding pan-cancer metabolic processes through variance in gene expression data’ European Journal of Cancer, vol. 103, no. 1, p. 318 Web

Publications from Postdoc research


26. Lukose, V.,  Walvoort, M. T. C., Imperiali, B. (2017) ‘Bacterial phosphoglycosyl transferases: initiators of glycan biosynthesis at the membrane interface’ Glycobiology, vol 27, no. 9, pp. 820 -833. Web

25. Bdira, F. B., Kallemeijn, W. W., Oussoren, S. V., Scheij, S., Bleijlevens, B., Florea, B. I., van Roomen, C. P. A. A., Ottenhoff, R., van Kooten, M. J. F. M., Walvoort, M. T. C., Witte, M. D., Boot, R. G., Ubbink, M., Overkleeft, H. S., Aerts, J. M. F. G. (2017) ‘Stabilization of Glucocerebrosidase by Active Site Occupancy’ ACS Chemical Biology, vol 12, no. 7, pp. 1830-1841. Web


24. Walvoort, M. T. C.,# Testa, C.,# Eilam, R., Aharoni, R., Nuti, F., Rossi, G., Real-Fernandez, F., Lanzillo, R., Brescia, Morra, V., Lolli, F., Rovero, P., Papini, A. M., Imperiali, B. (2016) ‘Antibodies from multiple sclerosis patients preferentially recognize hyperglucosylated adhesin of non-​typeable Haemophilus influenzae’ Scientific Reports, vol 6, pp. 39430. Web

23. Das, D., Walvoort, M. T. C., Lukose, V., Imperiali, B. (2016) ‘A Rapid and Efficient Luminescence-​based Method for Assaying Phosphoglycosyltransferase Enzymes’ Scientific Reports, vol 6, pp. 33412. Web

22. Walvoort, M.T.C., Lukose, V., Imperiali, B. (2016) ‘A modular approach to phosphoglycosyltransferase inhibitors inspired by nucleoside antibiotics’ Chemistry ­A European Journal, vol 22, pp. 3856-3864. Web

Publications from PhD research


21. Zhang, Q., van Rijssel, E.R., Walvoort, M.T.C., Overkleeft, H.S., van der Marel, G.A., Codée, J.D.C. (2015) ‘Acceptor reactivity in the total synthesis of alginate fragments containing α-L-guluronic acid and β-D-mannuronic acid’ Angewandte Chemie International Edition, vol 54, no. 26, pp. 7670-7673. Web


20. Kallemeijn, W.W., Witte, M.D., Voorn-Brouwer, T.M., Walvoort, M.T.C., Li, K.-Y., Codée, J.D.C., van der Marel, G.A., Boot, R.G., Overkleeft, H.S., Aerts, J.M.F.G. (2014) ‘A sensitive gel-based method combining distinct cyclophellitol-based probes for the identification of acid/base residues in human retaining β-glucosidases’ Journal of Biological Chemistry, vol 289, pp. 35351-35362. Web

19. Li, K.-Y., Kallemeijn, W.W., Jiang, J., Walvoort, M.T.C., Willems, L.I., Beenakker, T., van den Elst, H., van der Marel, G.A., Codée, J.D.C., Aerts, J.M.F.G., Florea, B., Boot, R., Witte, M.D., Overkleeft, H.S. (2014) ‘Rational design of activity-based retaining β-exoglucosidase probes’ Concepts and Case Studies in Chemical Biology, Ch. 13, p. 191.

18. Baker, P., Ricer, T., Moynihan, P.J., Kitova, E.N., Walvoort, M.T.C., Little, D.J., Whitney, J.C., Dawson, K., Weadge, J.T., Robinson, H., Ohman, D.E., Codée, J.D.C., Klassen, J.S., Clarke, A.J., Howell, P.J. (2014) ‘P. aeroginosa SGNH hydrolase-like proteins AlgJ and AlgX have similar topology but separate and distinct roles in alginate acetylation’ PLoS Pathogens, vol 10, e1004334. Web

17. Wolfram, F., Kitova, E.N., Robinson, H., Walvoort, M.T.C., Codée, J.D.C., Klassen, J.S., Howell, P.L. (2014) ‘Catalytic mechanism and mode of action of the periplasmic alginate epimerase AlgG. Journal of Biological Chemistry, vol 289, pp. 6006-6019. Web


16. Rönnols, J., Walvoort, M.T.C., van der Marel, G.A., Codée, J.D.C., Widmalm, G. (2013) ‘Chair interconversion and reactivity of mannuronic acid esters’ Organic and Biomolecular Chemistry, vol 11, pp. 8127-8134. Web

15. Frihed, T.G., Walvoort, M.T.C., Codée, J.D.C., van der Marel, G.A., Bols, M., Pedersen, C.M. (2013) ‘Influence of O6 in mannosylations using benzylidene protected donors: stereoelectronic or conformational effects?’ The Journal of Organic Chemistry, vol 78, no. 6, pp. 2191-2205. Web

14. Walvoort, M.T.C., van der Marel, G.A., Overkleeft, H.S., Codée, J.D.C. (2013) ‘On the reactivity and selectivity of donor glycosides in glycochemistry and glycobiology: trapped covalent intermediates’ Chemical Science, vol 4, pp. 897-906. Web

13. Walvoort, M.T.C., Kallemeijn, W.W., Willems, L.I., Witte, M.D., Aerts, J.M.F.G., van der Marel, G.A., Codée, J.D.C., Overkleeft, H.S. (2013) ‘Tuning the leaving group in 2-deoxy-2-fluoroglucoside results in improved activity-based retaining β-glucosidase probes’ Chemical Communications, vol 48, pp. 10386-10388. (Featured on the cover) Web


12. Kallemeijn, W.W., Li, K.-Y., Witte, M.D., Marques, A.R.A., Aten, J., Scheij, S., Jiang, J., Willems, L.I., Voorn-Brouwer, T.M., van Roomen, C.P.A.A., Ottenhoff, R., Boot, R.G., van den Elst, H., Walvoort, M.T.C., Florea, B.I., Codée, J.D.C., van der Marel, G.A., Aerts, J.M.F.G., Overkleeft, H.S. (2012) ‘Novel activity-based probes for broad-spectrum profiling of retaining β-exoglucosidases in situ and in vivo’ Angewandte Chemie International Edition, vol 51, no. 50, pp. 12529-12533. Web

11. Walvoort, M.T.C., Volbeda, G.A., Reintjens, N.R.M., van den Elst, H., Plante, O.J., Overkleeft, H.S., van der Marel, G.A., Codée, J.D.C. (2012) ‘Automated solid-phase synthesis of hyaluronan oligosaccharides’ Organic Letters, vol 14, no. 14, pp. 3776-3779. Web

10. Walvoort, M.T.C.,# van den Elst,# H., Plante, O.J., Kröck, L., Seeberger, P.H., Overkleeft, H.S., van der Marel, G.A., Codée, J.D.C. (2012) ‘Automated solid-phase synthesis of β-mannuronic acid alginates’ Angewandte Chemie International Edition, vol 51, no. 18, pp. 4393-4396. (Featured on the cover, and highlighted by Nature Chemical Biology 2012, 8, 321). Web


9. Walvoort, M.T.C., de Witte, W., van Dijk, J., Dinkelaar, J., Lodder, G., Overkleeft, H.S., Codée, J.D.C., van der Marel, G.A. (2011) ‘Mannopyranosyl uronic acid donor reactivity’ Organic Letters, vol 13, no. 16, pp. 4360-4363. Web

8. Walvoort, M.T.C., Sail, D., van der Marel, G.A., Codée, J.D.C. (2011) ‘Synthesis of methyl glycuronates by stereo- and regioselective TEMPO/BAIB-oxidation’ Carbohydrate Chemistry Proven Methods, vol 1, Ch. 11, p. 99.

7. Walvoort, M.T.C., Moggré, G.-J., Lodder, G., Overkleeft, H.S., Codée, J.D.C., van der Marel, G.A. (2011) ‘Stereoselective synthesis of 2,3-diamino-2,3-dideoxy-β-D-mannopyranosyl uronates’ The Journal of Organic Chemistry, vol 76, no. 18, pp. 7301-7315. (Featured on the cover) Web

6. Codée, J.D.C., Christina, A.E., Walvoort, M.T.C., Overkleeft, H.S., van der Marel, G.A. (2011) ‘Uronic acids in oligosaccharide and glycoconjugate synthesis’ Topics in Current Chemistry, vol 301, pp. 253-289.

5. Codée, J.D.C., Walvoort, M.T.C., de Jong, A.-R., Dinkelaar, J., Lodder, G., Overkleeft, H.S., van der Marel, G.A. (2011) ‘Mannuronic acids: reactivity and selectivity’ Journal of Carbohydrate Chemistry, vol 30, pp. 438-457.

4. Witte, M.D.,# Walvoort, M.T.C.,# Li, K.-Y., Kallemeijn, W.W., Donker-Koopman, W.E., Boot, R.G., Aerts, J.M.F.G., Codée, J.D.C., van der Marel, G.A., Overkleeft, H.S. (2011) ‘Activity-based profiling of retaining β-glucosidases: a comparative study’ ChemBioChem, vol 12, no. 8, pp. 1263-1269. Web


3. Walvoort, M.T.C., Dinkelaar, J., van den Bos, L.J., Lodder, G., Overkleeft, H.S., Codée, J.D. C., van der Marel, G.A. (2010) ‘The impact of oxacarbenium ion conformers on the stereochemical outcome of glycosylations’ Carbohydrate Research, vol 345, no. 10, pp. 1252-1263. Web

2. Walvoort, M.T.C., Lodder, G., Overkleeft, H.S., Codée, J.D.C., van der Marel, G.A. (2010) ‘Mannosazide methyl uronate donors. Glycosylating properties and use in the construction of β-ManNAcA-containing oligosaccharides’ Journal of Organic Chemistry, vol 75, no. 23, pp. 7990-8002. Web


1. Walvoort, M.T.C., Lodder, G., Mazurek, J., Overkleeft, H.S., Codée, J.D.C., van der Marel, G. A. (2009) ‘Equatorial anomeric triflates from mannuronic acid esters’ Journal of the American Chemical Society, vol 131, no. 34, pp. 12080-12081. Web