Publications of the Walvoort Lab
Full list of publications here
* indicates corresponding author, # denotes equal contribution
2025
59. Ferrari, M., van Leeuwen, S.S., de Vos, P., Jurak, E., Walvoort, M.T.C.* (2025) ‘Impact of GOS and 2’-FL on the production and structural composition of membrane-associated exopolysaccharides by B. adolescentis and B. infantis‘ Carbohydrate Polymers, vol. 347, 122660 Web
58. Akkerman, R., Oerlemans, M.M.P., Ferrari, M., Fernández-Lainez, C., Walvoort, M.T.C., de Vos, P. (2025) ‘Exopolysaccharides from Bifidobacterium longum subsp. infantis and Bifidobacterium adolescentis modulate Toll-like receptor signaling’ Carbohydrate Polymers, vol. 349, 123017 Web
2024
57. Chen, X., Gasaly, N., Tang, X., Walvoort, M.T.C., de Vos, P. (2024) ‘The effect of nerve cells on the intestinal barrier function and the influence of human milk oligosaccharides (hMOs) on the intestinal neuro-epithelial crosstalk’ Current Research in Food Science, vol. 9, 100851 Web
56. ‘Resolving Atomic-Level Dynamics and Interactions of High-Molecular-Weight Hyaluronic Acid by Multidimensional Solid-State NMR’ ACS Applied Materials & Interfaces, vo. 16, p. 43317–43328 Web
55. ‘Gut Epithelial Barrier Function is Impacted by Hyperglycemia and Secondary Bile Acids in Vitro: Possible Rescuing Effects of Specific Pectins’ Molecular Nutrition & Food Research, vol. 68, 2300910 Web
54. ández-Lainez, C., ‘Exopolysaccharide β-(2,6)-levan-type fructans have a molecular-weight-dependent modulatory effect on Toll-like receptor signalling’ Food & Function, vol. 15, p. 676-688 Web
53. ‘Practical Site-Selective Oxidation of Glycosides with Palladium(II) Acetate/Neocuproine’ SYNLETT, vol. 35, p. 1291-1295 Web
2023
52. ée, J.D.C., ‘Pseudomonas aeruginosa AlgF is a protein-protein interaction mediator required for acetylation of the alginate exopolysaccharide’ Journal of Biological Chemistry, vol. 299, 105314 Web
51. Ziylan, Z.S., de Putter, G.J., Roelofs, M., van Dijl, J.M., Scheffer, D.J., Walvoort, M.T.C.* (2023) ‘Evaluation of Kdo-8-N3 incorporation into lipopolysaccharides of various Escherichia coli strains’ RSC Chemical Biology, vol. 4, 884-893 Web
This article is part of the themed collection: 2023 RSC Chemical Biology Emerging Investigators
50. Tang, X., Beukema, M., Ferrari, M., Walvoort, M.T.C., de Haan, B.J., de Vos, P. (2023) ‘Efficacy of pectins with different degrees of methyl-esterification and of blockiness in preventing gut epithelial cell barrier disruption and the impact on sodium-glucose co-transporter expression under low and high glucose conditions’ Food & Function, vol. 14, 6226-6235 Web
49. Rampratap, P., Lasorsa, A., Perrone, B., van der Wel, P.C.A,* Walvoort, M.T.C.* (2023) ‘Production of isotopically enriched high molecular weight hyaluronic acid and characterization by solid-state NMR’ Carbohydrate Polymers, vol. 316, 121063 Web
2022
48. Gheorghita, A.A., Li, Y.E., Kitova, E.N., Bui, D.T., Pfoh, R., Low, K.E., Whitfield, G.B., Walvoort, M.T.C., Zhang, Q., Codée, J.D.C., Klassen, J.S., Howell, P.L. (2022) ‘Structure of the AlgKX modification and secretion complex required for alginate production and biofilm attachment in Pseudomonas aeruginosa‘ Nature Communications, vol. 13, p. 7631 Web
47. Versloot, R.C.A., Lucas, F.L.R., Yakovlieva, L., Tadema, M.J., Zhang, Y., Wood, T.M., Martin, N.I., Marrink, S.J., Walvoort, M.T.C.*, Maglia, G.* (2022) ‘Quantification of protein glycosylation using nanopores’ Nano Letters, vol. 22, no. 13, p. 5357-5364 Web
46. Reintjens, N.R.M.,# Yakovlieva, L.,# Marinus, N., Hekelaar, J., Nuti, F., Papini, A.M., Witte, M.D., Minnaard, A.J., Walvoort, M.T.C.* (2022) ‘Palladium-catalyzed oxidation of glucose in glycopeptides’ European Journal of Organic Chemistry, vol. 2022, no. 25, p. e202200677 Web
45. Ferrari, M., Hameleers, L., Stuart, M.C.A., Oerlemans, M.M.P., de Vos, P., Jurak, E., Walvoort, M.T.C.* (2022) ‘Efficient isolation of membrane-associated exopolysaccharides of four commercial bifidobacterial strains’ Carbohydrate Polymers, vol. 278, p. 118913 Web
2021
44. Lucas, F.L.R., Versloot, R.C.A., Yakovlieva, L., Walvoort, M.T.C., Maglia, G. (2021) ‘Protein identification by nanopore peptide profiling’ Nature Communications, vol. 12, no. 1, p. 1-9 Web
43. Yakovlieva, L., Fülleborn, J., Walvoort, M.T.C.* (2021) ‘Opportunities and challenges of bacterial glycosylation for the development of novel antibacterial strategies’ Frontiers in Microbiology, vol. 12, p. 745702 Web
42. Marinus, N., van Dijk, J.H.M., Walvoort, M.T.C., Witte, M.D., Minnaard, A.J. (2021) ‘Chapter 16: Regioselective palladium catalyzed oxidation at C-3 of methyl glucoside’ Carbohydrate Chemistry: Proven Synthetic Methods, vol. 5, Eds. Kosma, Wrodnigg, Stütz.
41. Yakovlieva, L., Ramirez-Palacios, C., Marrink, S.J., Walvoort, M.T.C.* (2021) ‘Semiprocessive hyperglycosylation of adhesin by bacterial protein N-glycosyltransferases’ ACS Chemical Biology, vol. 16, no. 1, p. 165-175 Web
40. Yakovlieva, L.,# Wood, T.M.,# Kemmink, J., Kotsogianni, I., Koller, R., Lassak, J., Martin, N.I.,* Walvoort, M.T.C.* (2021) ‘A β-hairpin epitope as novel structural requirement for protein arginine rhamnosylation’ Chemical Science, vol. 12, p. 1560-1567 Web
39. Oerlemans, M.M.P., Akkerman, R., Ferrari, M., Walvoort, M.T.C., de Vos, P. (2021) ‘Benefits of bacteria-derived exopolysaccharides on gastrointestinal microbiota, immunity and health’ Journal of Functional Foods, vol. 76, p. 104289 Web
38. Verkhnyatskaya, S.A., Kong, C., Klostermann, C., Schols, H.A., de Vos, P., Walvoort, M.T.C.* (2021) ‘Digestion, fermentation, and pathogen anti-adhesive properties of the hMO-mimic di-fucosyl-β-cyclodextrin’ Food & Function, vol. 12, p. 5018-5026 Web
37. Leeuwenburgh, V.C., Urzúa-Traslaviña, C.G., Bhattacharya, A., Walvoort, M.T.C., Jalving, M., de Jong, S., Fehrmann, R.S.N. (2021) ‘Robust metabolic transcriptional components in 34,494 patient-derived cancer-related samples and cell lines’ BMC Cancer & Metabolism, vol. 9, p. 35 Web
2020
36. Cheng, L., Kiewiet, M.B.G., Logtenberg, M., Groeneveld, A., Nauta, A., Schols, H.A., Walvoort, M.T.C., Harmsen, H.J.M., de Vos, P. (2020) ‘Effects of different human milk oligosaccharides on growth of Bifidobacteria in monoculture and co-culture with Faecalibacterium prausnitzii‘ Frontiers in Microbiology, vol. 11, p. 569700 Web
35. Hu, S., Kuwabara, R., Beukema, M., Ferrari, M., de Haan, B.J., Walvoort, M.T.C., de Vos, P., Smink, S.M. (2020) ‘Low methyl-esterified pectin protects pancreatic β-cells against diabetes-induced oxidative and inflammatory stress via galectin-3’ Carbohydrate Polymers, vol. 249, p. 116863 Web
34. Kong, C., Cheng, L., Krenning, G., Fledderus, J., de Haan, B.J., Walvoort, M.T.C., de Vos, P. (2020) ‘Human milk oligosaccharides mediate the crosstalk between intestinal epithelial Caco-2 cells and Lactobacillus plantarum WCFS1 in an in vitro model with intestinal peristaltic shear force’ The Journal of Nutrition, vol. 150, no. 8, p. 2077-2088 Web
33. Cheng, L., Akkerman, R., Kong, C., Walvoort, M. T. C., de Vos, P. (2020) ‘More than sugar in the milk: human milk oligosaccharides as essential bioactive molecules in breast milk and current insight in beneficial effects’ Critical Reviews in Food Science and Nutrition, p. 1-17. Web
32. Zhang, J., Yakovlieva, L., de Haan, B. J., de Vos, P., Minnaard, A. J., Witte, M. D., Walvoort, M. T. C.* (2020) ‘Selective Modification of Streptozotocin at the C3 Position to Improve Its Bioactivity as Antibiotic and Reduce Its Cytotoxicity towards Insulin-Producing β Cells’ Antibiotics, vol. 9, no. 4, p. 182 Web
31. Yakovlieva, L., Walvoort, M. T. C.* (2020) ‘Processivity in Bacterial Glycosyltransferases’ ACS Chemical Biology, vol. 15, no. 1, pp. 3-16 Web
30. Cheng, L., Kong, C., Walvoort, M. T. C., Faas, M. M., de Vos, P. (2020) ‘Human Milk Oligosaccharides Differently Modulate Goblet Cells Under Homeostatic, Proinflammatory Conditions and ER Stress’ Molecular Nutrition & Food Research, vol. 64, no. 5, p.1900976 Web
2019
29. Verkhnyatskaya, S. A., de Vries, A. H., Douma-de Vries, E., Sneep, E. J. L., Walvoort, M. T. C.* (2019) ‘Direct and Regioselective Di-alpha-fucosylation on the Secondary Rim of beta-Cyclodextrin’ Chemistry A European Journal, vol. 25, no. 27, pp. 6722-6727 Web
with Front Cover art, and author profile: Chemistry A European Journal, vol. 25, no. 27, p. 6649 Web
28. Verkhnyatskaya, S., Ferrari, M., de Vos, P., Walvoort, M. T. C.* (2019) ‘Shaping the Infant Microbiome With Non-digestible Carbohydrates’ Frontiers in Microbiology, vol. 10, no. 343 Web
2018
27. Leeuwenburgh, V., Bhattacharya, A., Urzua, C., Walvoort, M., Jalving, H., de Jong, S., Fehrmann, R. (2018) ‘The metabolic landscape browser: a novel tool for understanding pan-cancer metabolic processes through variance in gene expression data’ European Journal of Cancer, vol. 103, no. 1, p. 318 Web
Publications from Postdoc research
2017
26. Lukose, V., Walvoort, M. T. C., Imperiali, B. (2017) ‘Bacterial phosphoglycosyl transferases: initiators of glycan biosynthesis at the membrane interface’ Glycobiology, vol 27, no. 9, pp. 820 -833. Web
25. Bdira, F. B., Kallemeijn, W. W., Oussoren, S. V., Scheij, S., Bleijlevens, B., Florea, B. I., van Roomen, C. P. A. A., Ottenhoff, R., van Kooten, M. J. F. M., Walvoort, M. T. C., Witte, M. D., Boot, R. G., Ubbink, M., Overkleeft, H. S., Aerts, J. M. F. G. (2017) ‘Stabilization of Glucocerebrosidase by Active Site Occupancy’ ACS Chemical Biology, vol 12, no. 7, pp. 1830-1841. Web
2016
24. Walvoort, M. T. C.,# Testa, C.,# Eilam, R., Aharoni, R., Nuti, F., Rossi, G., Real-Fernandez, F., Lanzillo, R., Brescia, Morra, V., Lolli, F., Rovero, P., Papini, A. M., Imperiali, B. (2016) ‘Antibodies from multiple sclerosis patients preferentially recognize hyperglucosylated adhesin of non-typeable Haemophilus influenzae’ Scientific Reports, vol 6, pp. 39430. Web
23. Das, D., Walvoort, M. T. C., Lukose, V., Imperiali, B. (2016) ‘A Rapid and Efficient Luminescence-based Method for Assaying Phosphoglycosyltransferase Enzymes’ Scientific Reports, vol 6, pp. 33412. Web
22. Walvoort, M.T.C., Lukose, V., Imperiali, B. (2016) ‘A modular approach to phosphoglycosyltransferase inhibitors inspired by nucleoside antibiotics’ Chemistry A European Journal, vol 22, pp. 3856-3864. Web
Publications from PhD research
2015
21. Zhang, Q., van Rijssel, E.R., Walvoort, M.T.C., Overkleeft, H.S., van der Marel, G.A., Codée, J.D.C. (2015) ‘Acceptor reactivity in the total synthesis of alginate fragments containing α-L-guluronic acid and β-D-mannuronic acid’ Angewandte Chemie International Edition, vol 54, no. 26, pp. 7670-7673. Web
2014
20. Kallemeijn, W.W., Witte, M.D., Voorn-Brouwer, T.M., Walvoort, M.T.C., Li, K.-Y., Codée, J.D.C., van der Marel, G.A., Boot, R.G., Overkleeft, H.S., Aerts, J.M.F.G. (2014) ‘A sensitive gel-based method combining distinct cyclophellitol-based probes for the identification of acid/base residues in human retaining β-glucosidases’ Journal of Biological Chemistry, vol 289, pp. 35351-35362. Web
19. Li, K.-Y., Kallemeijn, W.W., Jiang, J., Walvoort, M.T.C., Willems, L.I., Beenakker, T., van den Elst, H., van der Marel, G.A., Codée, J.D.C., Aerts, J.M.F.G., Florea, B., Boot, R., Witte, M.D., Overkleeft, H.S. (2014) ‘Rational design of activity-based retaining β-exoglucosidase probes’ Concepts and Case Studies in Chemical Biology, Ch. 13, p. 191.
18. Baker, P., Ricer, T., Moynihan, P.J., Kitova, E.N., Walvoort, M.T.C., Little, D.J., Whitney, J.C., Dawson, K., Weadge, J.T., Robinson, H., Ohman, D.E., Codée, J.D.C., Klassen, J.S., Clarke, A.J., Howell, P.J. (2014) ‘P. aeroginosa SGNH hydrolase-like proteins AlgJ and AlgX have similar topology but separate and distinct roles in alginate acetylation’ PLoS Pathogens, vol 10, e1004334. Web
17. Wolfram, F., Kitova, E.N., Robinson, H., Walvoort, M.T.C., Codée, J.D.C., Klassen, J.S., Howell, P.L. (2014) ‘Catalytic mechanism and mode of action of the periplasmic alginate epimerase AlgG. Journal of Biological Chemistry, vol 289, pp. 6006-6019. Web
2013
16. Rönnols, J., Walvoort, M.T.C., van der Marel, G.A., Codée, J.D.C., Widmalm, G. (2013) ‘Chair interconversion and reactivity of mannuronic acid esters’ Organic and Biomolecular Chemistry, vol 11, pp. 8127-8134. Web
15. Frihed, T.G., Walvoort, M.T.C., Codée, J.D.C., van der Marel, G.A., Bols, M., Pedersen, C.M. (2013) ‘Influence of O6 in mannosylations using benzylidene protected donors: stereoelectronic or conformational effects?’ The Journal of Organic Chemistry, vol 78, no. 6, pp. 2191-2205. Web
14. Walvoort, M.T.C., van der Marel, G.A., Overkleeft, H.S., Codée, J.D.C. (2013) ‘On the reactivity and selectivity of donor glycosides in glycochemistry and glycobiology: trapped covalent intermediates’ Chemical Science, vol 4, pp. 897-906. Web
13. Walvoort, M.T.C., Kallemeijn, W.W., Willems, L.I., Witte, M.D., Aerts, J.M.F.G., van der Marel, G.A., Codée, J.D.C., Overkleeft, H.S. (2013) ‘Tuning the leaving group in 2-deoxy-2-fluoroglucoside results in improved activity-based retaining β-glucosidase probes’ Chemical Communications, vol 48, pp. 10386-10388. (Featured on the cover) Web
2012
12. Kallemeijn, W.W., Li, K.-Y., Witte, M.D., Marques, A.R.A., Aten, J., Scheij, S., Jiang, J., Willems, L.I., Voorn-Brouwer, T.M., van Roomen, C.P.A.A., Ottenhoff, R., Boot, R.G., van den Elst, H., Walvoort, M.T.C., Florea, B.I., Codée, J.D.C., van der Marel, G.A., Aerts, J.M.F.G., Overkleeft, H.S. (2012) ‘Novel activity-based probes for broad-spectrum profiling of retaining β-exoglucosidases in situ and in vivo’ Angewandte Chemie International Edition, vol 51, no. 50, pp. 12529-12533. Web
11. Walvoort, M.T.C., Volbeda, G.A., Reintjens, N.R.M., van den Elst, H., Plante, O.J., Overkleeft, H.S., van der Marel, G.A., Codée, J.D.C. (2012) ‘Automated solid-phase synthesis of hyaluronan oligosaccharides’ Organic Letters, vol 14, no. 14, pp. 3776-3779. Web
10. Walvoort, M.T.C.,# van den Elst,# H., Plante, O.J., Kröck, L., Seeberger, P.H., Overkleeft, H.S., van der Marel, G.A., Codée, J.D.C. (2012) ‘Automated solid-phase synthesis of β-mannuronic acid alginates’ Angewandte Chemie International Edition, vol 51, no. 18, pp. 4393-4396. (Featured on the cover, and highlighted by Nature Chemical Biology 2012, 8, 321). Web
2011
9. Walvoort, M.T.C., de Witte, W., van Dijk, J., Dinkelaar, J., Lodder, G., Overkleeft, H.S., Codée, J.D.C., van der Marel, G.A. (2011) ‘Mannopyranosyl uronic acid donor reactivity’ Organic Letters, vol 13, no. 16, pp. 4360-4363. Web
8. Walvoort, M.T.C., Sail, D., van der Marel, G.A., Codée, J.D.C. (2011) ‘Synthesis of methyl glycuronates by stereo- and regioselective TEMPO/BAIB-oxidation’ Carbohydrate Chemistry Proven Methods, vol 1, Ch. 11, p. 99.
7. Walvoort, M.T.C., Moggré, G.-J., Lodder, G., Overkleeft, H.S., Codée, J.D.C., van der Marel, G.A. (2011) ‘Stereoselective synthesis of 2,3-diamino-2,3-dideoxy-β-D-mannopyranosyl uronates’ The Journal of Organic Chemistry, vol 76, no. 18, pp. 7301-7315. (Featured on the cover) Web
6. Codée, J.D.C., Christina, A.E., Walvoort, M.T.C., Overkleeft, H.S., van der Marel, G.A. (2011) ‘Uronic acids in oligosaccharide and glycoconjugate synthesis’ Topics in Current Chemistry, vol 301, pp. 253-289.
5. Codée, J.D.C., Walvoort, M.T.C., de Jong, A.-R., Dinkelaar, J., Lodder, G., Overkleeft, H.S., van der Marel, G.A. (2011) ‘Mannuronic acids: reactivity and selectivity’ Journal of Carbohydrate Chemistry, vol 30, pp. 438-457.
4. Witte, M.D.,# Walvoort, M.T.C.,# Li, K.-Y., Kallemeijn, W.W., Donker-Koopman, W.E., Boot, R.G., Aerts, J.M.F.G., Codée, J.D.C., van der Marel, G.A., Overkleeft, H.S. (2011) ‘Activity-based profiling of retaining β-glucosidases: a comparative study’ ChemBioChem, vol 12, no. 8, pp. 1263-1269. Web
2010
3. Walvoort, M.T.C., Dinkelaar, J., van den Bos, L.J., Lodder, G., Overkleeft, H.S., Codée, J.D. C., van der Marel, G.A. (2010) ‘The impact of oxacarbenium ion conformers on the stereochemical outcome of glycosylations’ Carbohydrate Research, vol 345, no. 10, pp. 1252-1263. Web
2. Walvoort, M.T.C., Lodder, G., Overkleeft, H.S., Codée, J.D.C., van der Marel, G.A. (2010) ‘Mannosazide methyl uronate donors. Glycosylating properties and use in the construction of β-ManNAcA-containing oligosaccharides’ Journal of Organic Chemistry, vol 75, no. 23, pp. 7990-8002. Web
2009
1. Walvoort, M.T.C., Lodder, G., Mazurek, J., Overkleeft, H.S., Codée, J.D.C., van der Marel, G. A. (2009) ‘Equatorial anomeric triflates from mannuronic acid esters’ Journal of the American Chemical Society, vol 131, no. 34, pp. 12080-12081. Web